Sherry F Queener Selected Research

Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)

10/2011	Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
3/2009	Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
8/2008	The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
7/2004	Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.
5/2004	Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.
5/2004	Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.
11/2003	Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
4/2003	Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
1/2003	Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.

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Sherry F Queener Research Topics

Disease

6	Acquired Immunodeficiency Syndrome (AIDS) 03/2009 - 01/2003
4	Infections 04/2013 - 11/2003
3	Opportunistic Infections (Opportunistic Infection) 01/2018 - 06/2013
3	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 10/2011 - 09/2002
1	Parasitic Diseases (Parasitic Disease) 10/2013
1	Toxoplasmosis 02/2010
1	Pneumonia (Pneumonitis) 03/2009
1	Malaria 03/2008
1	Neoplasms (Cancer) 07/2007
1	HIV Infections (HIV Infection) 04/2003

Drug/Important Bio-Agent (IBA)

9	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 10/2011 - 01/2003
4	PyrimidinesIBA 01/2018 - 11/2003
3	Biological ProductsIBA 01/2018 - 11/2003
3	Folic Acid AntagonistsIBA 01/2018 - 04/2003
3	Pharmaceutical PreparationsIBA 10/2013 - 09/2002
3	Trimethoprim (Proloprim)FDA LinkGeneric 10/2011 - 04/2003
3	Thymidine Monophosphate (TMP)IBA 10/2011 - 04/2003
2	EnzymesIBA 03/2009 - 04/2003
2	piritreximIBA 05/2004 - 04/2003
1	Amino Acids FDA Link 01/2018
1	Thymidylate SynthaseIBA 10/2013
1	Antiparasitic Agents (Antiparasitics)IBA 04/2013
1	pyrimidineIBA 08/2008
1	BiguanidesIBA 03/2008
1	4,6- diamino- 1,2- dihydro- 2,2- dimethyl- 1- (3- (2- chloro- 4- trifluoromethoxyphenoxy)propyloxy)- 1,3,5- triazineIBA 03/2008
1	BoronIBA 07/2007
1	nido-carboraneIBA 07/2007
1	Proteins (Proteins, Gene)FDA Link 04/2005
1	AzepinesIBA 05/2004
1	EstersIBA 05/2004
1	Antineoplastic Agents (Antineoplastics)IBA 11/2003
1	Oxidoreductases (Dehydrogenase)IBA 04/2003
1	dihydrofolateIBA 04/2003
1	Pyrimethamine (Daraprim)FDA Link 09/2002

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 03/2004 - 09/2002
1	Therapeutics 10/2011
1	Boron Neutron Capture Therapy 07/2007